The Role of Insulin-Like Growth Factor-1 And Growth Hormone in Breast Cancer

Abstract

Epidemiological data have attempted to clarify the role of the insulin-like growth factor-1 axis in human breast cancer and have yielded conflicting results. Studies have shown that increased levels of insulin-like growth factor-1 gene expression are associated with a better prognosis in breast cancer, and other authors have suggested that increased levels of insulin-like growth factor-1 gene expression may be associated with increased cell proliferation in breast cancer. Altered insulin-like growth factor-1 gene expression levels may be associated with better prognosis or poorer outcomes, as well as more aggressive breast cancer.